Detailed view for CT_675

Basic information

TDR Targets ID: 934848
Chlamydia trachomatis, arginine kinase
Source Database / ID:  KEGG  

pI: 6.4952 | Length (AA): 356 | MW (Da): 40244 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00217   ATP:guanido phosphotransferase, C-terminal catalytic domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016775   phosphotransferase activity, nitrogenous group as acceptor  
GO:0016772   transferase activity, transferring phosphorus-containing groups  
GO:0016301   kinase activity  
GO:0003824   catalytic activity  
GO:0006950   response to stress  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 354 4rf6 (A) 107 483 20.00 0 0.91 1.02308 0.86
3 249 1m15 (A) 100 356 24.00 0 1 0.99422 -0.42
26 276 4wod (A) 120 379 25.00 0 1 0.974456 0.13

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128330)

Species Accession Gene Product
Brugia malayi Bm1_37040   ATP:guanido phosphotransferase, C-terminal catalytic domain containing protein
Brugia malayi Bm1_23610   arginine kinase
Caenorhabditis elegans CELE_W10C8.5   Protein W10C8.5
Caenorhabditis elegans CELE_F32B5.1   Protein F32B5.1
Caenorhabditis elegans CELE_F46H5.3   Protein F46H5.3, isoform B
Caenorhabditis elegans CELE_F44G3.2   Protein F44G3.2
Caenorhabditis elegans CELE_ZC434.8   Protein ZC434.8
Chlamydia trachomatis CT_675   arginine kinase
Drosophila melanogaster Dmel_CG32031   Arginine kinase
Homo sapiens ENSG00000104879   creatine kinase, muscle
Homo sapiens ENSG00000166165   creatine kinase, brain
Loa Loa (eye worm) LOAG_10519   arginine kinase
Loa Loa (eye worm) LOAG_13628   hypothetical protein
Loa Loa (eye worm) LOAG_07634   ATP:guanido phosphotransferase
Mus musculus ENSMUSG00000001270   creatine kinase, brain
Mus musculus ENSMUSG00000030399   creatine kinase, muscle
Onchocerca volvulus OVOC4467  
Onchocerca volvulus OVOC2321  
Schistosoma japonicum Sjp_0200590   ko:K00933 creatine kinase [EC2.7.3.2], putative
Schistosoma japonicum Sjp_0124500   ATP:guanidino kinase SMC74, putative
Schistosoma mansoni Smp_194770   ATP:guanidino kinase (Smc74)
Schmidtea mediterranea mk4.004791.03  
Schmidtea mediterranea mk4.018687.00  
Schmidtea mediterranea mk4.002159.01  
Schmidtea mediterranea mk4.008532.00  
Schmidtea mediterranea mk4.001156.04  
Schmidtea mediterranea mk4.000513.00  
Schmidtea mediterranea mk4.007131.02  
Schmidtea mediterranea mk4.007502.01  
Trypanosoma brucei gambiense Tbg972.9.3300   arginine kinase
Trypanosoma brucei gambiense Tbg972.9.3260   arginine kinase
Trypanosoma brucei gambiense Tbg972.9.3280   arginine kinase
Trypanosoma brucei gambiense Tbg972.9.3250   arginine kinase
Trypanosoma brucei Tb927.9.6210   arginine kinase
Trypanosoma brucei Tb927.9.6250   arginine kinase
Trypanosoma brucei Tb927.9.6290   arginine kinase
Trypanosoma congolense TcIL3000_0_36630   arginine kinase
Trypanosoma congolense TcIL3000_9_2150   arginine kinase
Trypanosoma cruzi TcCLB.507241.30   arginine kinase
Toxoplasma gondii TGME49_231610   ATP:guanido phosphotransferase, C-terminal catalytic domain-containing protein

Essentiality

CT_675 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.160.4560 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.160.4560 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb09.160.4560 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.160.4560 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_231610 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Trypanosoma cruzi arginine kinase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier CT_675 (Chlamydia trachomatis), arginine kinase
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